Picomolar Inhibition of Plasmepsin V, an Essential Malaria Protease, Achieved Exploiting the Prime Region

Malaria is an infectious disease caused by Plasmodium parasites. It results in an annual death-toll of ~ 600,000. Resistance to all medications currently in use exists, and novel antimalarial drugs are urgently needed. Plasmepsin V (PmV) is an essential Plasmodium protease and a highly promising ant...

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Опубликовано в: :PLoS One
Главные авторы: Gambini, Luca, Rizzi, Luca, Pedretti, Alessandro, Taglialatela-Scafati, Orazio, Carucci, Mario, Pancotti, Andrea, Galli, Corinna, Read, Martin, Giurisato, Emanuele, Romeo, Sergio, Russo, Ilaria
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2015
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4643876/
https://ncbi.nlm.nih.gov/pubmed/26566224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0142509
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