Picomolar Inhibition of Plasmepsin V, an Essential Malaria Protease, Achieved Exploiting the Prime Region

Malaria is an infectious disease caused by Plasmodium parasites. It results in an annual death-toll of ~ 600,000. Resistance to all medications currently in use exists, and novel antimalarial drugs are urgently needed. Plasmepsin V (PmV) is an essential Plasmodium protease and a highly promising ant...

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Bibliografiske detaljer
Udgivet i:PLoS One
Main Authors: Gambini, Luca, Rizzi, Luca, Pedretti, Alessandro, Taglialatela-Scafati, Orazio, Carucci, Mario, Pancotti, Andrea, Galli, Corinna, Read, Martin, Giurisato, Emanuele, Romeo, Sergio, Russo, Ilaria
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4643876/
https://ncbi.nlm.nih.gov/pubmed/26566224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0142509
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