Structure-Activity Relationships and Pharmacophore Model of a Non-Competitive Pyrazoline Containing Class of GluN2C/GluN2D Selective Antagonists

Here we describe the synthesis and structure-activity relationship for a class of pyrazoline-containing dihydroquinolone negative allosteric modulators of the NMDA receptor that show strong subunit-selectivity for GluN2C- and GluN2D-containing receptors over GluN2A-and GluN2B-containing receptors. S...

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Xehetasun bibliografikoak
Argitaratua izan da:J Med Chem
Egile Nagusiak: Acker, Timothy M., Khatri, Alpa, Vance, Katie M., Slabber, Cathryn, Bacsa, John, Snyder, James P., Traynelis, Stephen F., Liotta, Dennis C.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2013
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4643674/
https://ncbi.nlm.nih.gov/pubmed/23909910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm400652r
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