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Effects of hypertonic buffer composition on lymph node uptake and bioavailability of rituximab, after subcutaneous administration
Subcutaneous administration of biologics is highly desirable; however, incomplete bioavailability after sc administration remains a major challenge. In this work we investigated the effects of excipient dependent hyper-osmolarity on lymphatic uptake and plasma exposure of rituximab as a model protei...
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| Udgivet i: | Biopharm Drug Dispos |
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| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4643658/ https://ncbi.nlm.nih.gov/pubmed/25377184 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bdd.1925 |
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