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Local 3D matrix microenvironment regulates cell migration through spatiotemporal dynamics of contractility-dependent adhesions

The physical properties of two-dimensional (2D) extracellular matrices (ECMs) modulate cell adhesion dynamics and motility, but little is known about the roles of local microenvironmental differences in three-dimensional (3D) ECMs. Here we generate 3D collagen gels of varying matrix microarchitectur...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Doyle, Andrew D., Carvajal, Nicole, Jin, Albert, Matsumoto, Kazue, Yamada, Kenneth M.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4643399/
https://ncbi.nlm.nih.gov/pubmed/26548801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9720
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