Identification of neurotoxic cytokines by profiling Alzheimer’s disease tissues and neuron culture viability screening

Alzheimer’s disease (AD) therapeutics based on the amyloid hypothesis have shown minimal efficacy in patients, suggesting that the activity of amyloid beta (Aβ) represents only one aspect of AD pathogenesis. Since neuroinflammation is thought to play an important role in AD, we hypothesized that cyt...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Wood, Levi B., Winslow, Ashley R., Proctor, Elizabeth A., McGuone, Declan, Mordes, Daniel A., Frosch, Matthew P., Hyman, Bradley T., Lauffenburger, Douglas A., Haigis, Kevin M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4643219/
https://ncbi.nlm.nih.gov/pubmed/26564777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep16622
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