Imaging Sites of Inhibition of Proteolysis in Pathomimetic Human Breast Cancer Cultures by Light-Activated Ruthenium Compound

The cysteine protease cathepsin B has been causally linked to progression and metastasis of breast cancers. We demonstrate inhibition by a dipeptidyl nitrile inhibitor (compound 1) of cathepsin B activity and also of pericellular degradation of dye-quenched collagen IV by living breast cancer cells....

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Veröffentlicht in:PLoS One
Hauptverfasser: Ramalho, Suelem D., Sharma, Rajgopal, White, Jessica K., Aggarwal, Neha, Chalasani, Anita, Sameni, Mansoureh, Moin, Kamiar, Vieira, Paulo C., Turro, Claudia, Kodanko, Jeremy J., Sloane, Bonnie F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2015
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4643019/
https://ncbi.nlm.nih.gov/pubmed/26562785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0142527
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