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Label-free quantitative phosphoproteomics with novel pairwise abundance normalization reveals synergistic RAS and CIP2A signaling

Hyperactivated RAS drives progression of many human malignancies. However, oncogenic activity of RAS is dependent on simultaneous inactivation of protein phosphatase 2A (PP2A) activity. Although PP2A is known to regulate some of the RAS effector pathways, it has not been systematically assessed how...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Kauko, Otto, Laajala, Teemu Daniel, Jumppanen, Mikael, Hintsanen, Petteri, Suni, Veronika, Haapaniemi, Pekka, Corthals, Garry, Aittokallio, Tero, Westermarck, Jukka, Imanishi, Susumu Y.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4642524/
https://ncbi.nlm.nih.gov/pubmed/26278961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep13099
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