Regulation of iron homeostasis by the p53-ISCU pathway

Accumulation of iron in tissues increases the risk of cancer, but iron regulatory mechanisms in cancer tissues are largely unknown. Here, we report that p53 regulates iron metabolism through the transcriptional regulation of ISCU (iron-sulfur cluster assembly enzyme), which encodes a scaffold protei...

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Udgivet i:Sci Rep
Main Authors: Funauchi, Yuki, Tanikawa, Chizu, Yi Lo, Paulisally Hau, Mori, Jinichi, Daigo, Yataro, Takano, Atsushi, Miyagi, Yohei, Okawa, Atsushi, Nakamura, Yusuke, Matsuda, Koichi
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4642350/
https://ncbi.nlm.nih.gov/pubmed/26560363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep16497
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