Regulation of iron homeostasis by the p53-ISCU pathway

Accumulation of iron in tissues increases the risk of cancer, but iron regulatory mechanisms in cancer tissues are largely unknown. Here, we report that p53 regulates iron metabolism through the transcriptional regulation of ISCU (iron-sulfur cluster assembly enzyme), which encodes a scaffold protei...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Sci Rep
Päätekijät: Funauchi, Yuki, Tanikawa, Chizu, Yi Lo, Paulisally Hau, Mori, Jinichi, Daigo, Yataro, Takano, Atsushi, Miyagi, Yohei, Okawa, Atsushi, Nakamura, Yusuke, Matsuda, Koichi
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group 2015
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4642350/
https://ncbi.nlm.nih.gov/pubmed/26560363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep16497
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