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Mammalian target of rapamycin complex 1 (mTORC1) is required for mouse spermatogonial differentiation in vivo

Spermatogonial stem cells (SSCs) must balance self-renewal with production of transit-amplifying progenitors that differentiate in response to retinoic acid (RA) before entering meiosis. This self-renewal vs. differentiation spermatogonial fate decision is critical for maintaining tissue homeostasis...

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Bibliografske podrobnosti
izdano v:Dev Biol
Main Authors: Busada, Jonathan T., Niedenberger, Bryan A., Velte, Ellen K., Keiper, Brett D., Geyer, Christopher B.
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4641790/
https://ncbi.nlm.nih.gov/pubmed/26254600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2015.08.004
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