Toll-Like Receptor 2 Targeted Rectification of Impaired CD8(+) T Cell Functions in Experimental Leishmania donovani Infection Reinstates Host Protection

Leishmania donovani, a protozoan parasite, causes the disease visceral leishmanisis (VL), characterized by inappropriate CD8(+) T-cell activation. Therefore, we examined whether the Toll-like Receptor 2 (TLR2) ligand Ara-LAM, a cell wall glycolipid from non-pathogenic Mycobacterium smegmatis, would...

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Detalles Bibliográficos
Publicado en:PLoS One
Main Authors: Bandyopadhyay, Syamdas, Kar Mahapatra, Santanu, Paul Chowdhury, Bidisha, Kumar Jha, Mukesh, Das, Shibali, Halder, Kuntal, Bhattacharyya Majumdar, Suchandra, Saha, Bhaskar, Majumdar, Subrata
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2015
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4641719/
https://ncbi.nlm.nih.gov/pubmed/26559815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0142800
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