Toll-Like Receptor 2 Targeted Rectification of Impaired CD8(+) T Cell Functions in Experimental Leishmania donovani Infection Reinstates Host Protection

Leishmania donovani, a protozoan parasite, causes the disease visceral leishmanisis (VL), characterized by inappropriate CD8(+) T-cell activation. Therefore, we examined whether the Toll-like Receptor 2 (TLR2) ligand Ara-LAM, a cell wall glycolipid from non-pathogenic Mycobacterium smegmatis, would...

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Vydáno v:PLoS One
Hlavní autoři: Bandyopadhyay, Syamdas, Kar Mahapatra, Santanu, Paul Chowdhury, Bidisha, Kumar Jha, Mukesh, Das, Shibali, Halder, Kuntal, Bhattacharyya Majumdar, Suchandra, Saha, Bhaskar, Majumdar, Subrata
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2015
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4641719/
https://ncbi.nlm.nih.gov/pubmed/26559815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0142800
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