Mechanical fibrinogen-depletion supports heparin-free mesenchymal stem cell propagation in human platelet lysate

BACKGROUND: Pooled human platelet lysate (pHPL) is an efficient alternative to xenogenic supplements for ex vivo expansion of mesenchymal stem cells (MSCs) in clinical studies. Currently, porcine heparin is used in pHPL-supplemented medium to prevent clotting due to plasmatic coagulation factors. We...

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Publicado en:J Transl Med
Autores principales: Laner-Plamberger, Sandra, Lener, Thomas, Schmid, Doris, Streif, Doris A., Salzer, Tina, Öller, Michaela, Hauser-Kronberger, Cornelia, Fischer, Thorsten, Jacobs, Volker R., Schallmoser, Katharina, Gimona, Mario, Rohde, Eva
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4641400/
https://ncbi.nlm.nih.gov/pubmed/26554451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-015-0717-4
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