Cyclic helix B peptide inhibits ischemia reperfusion-induced renal fibrosis via the PI3K/Akt/FoxO3a pathway

Renal fibrosis is a main cause of end-stage renal disease. Clinically, there is no beneficial treatment that can effectively reverse the progressive loss of renal function. We recently synthesized a novel proteolysis-resistant cyclic helix B peptide (CHBP) that exhibits promising renoprotective effe...

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Bibliografske podrobnosti
izdano v:J Transl Med
Main Authors: Yang, Cheng, Cao, Ye, Zhang, Yi, Li, Long, Xu, Ming, Long, Yaqiu, Rong, Ruiming, Zhu, Tongyu
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2015
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4641348/
https://ncbi.nlm.nih.gov/pubmed/26554357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-015-0699-2
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