Wnt5a attenuates the pathogenic effects of the Wnt/β-catenin pathway in human retinal pigment epithelial cells via down-regulating β-catenin and Snail

Activation of the Wnt/β-catenin pathway plays a pathogenic role in age-related macular degeneration (AMD) and is thus a potential target for the development of therapeutics for this disease. Here, we demonstrated that Wnt5a antagonized β-catenin response transcription (CRT) induced with Wnt3a by pro...

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Publicat a:BMB Rep
Autors principals: Kim, Joo-Hyun, Park, Seoyoung, Chung, Hyewon, Oh, Sangtaek
Format: Artigo
Idioma:Inglês
Publicat: Korean Society for Biochemistry and Molecular Biology 2015
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4641237/
https://ncbi.nlm.nih.gov/pubmed/26246285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5483/BMBRep.2015.48.9.140
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