The relation of circulating CC16 to lung function growth, decline, and development of COPD across the lifespan

BACKGROUND: Low serum levels of the anti-inflammatory club cell secretory protein (CC16) have been associated with an accelerated FEV1 decline in COPD. Whether low circulating CC16 precedes lung function deficits and incidence of COPD in the general population is unknown. METHODS: We used longitudin...

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Publié dans:Lancet Respir Med
Auteurs principaux: Guerra, Stefano, Halonen, Marilyn, Vasquez, Monica M, Spangenberg, Amber, Stern, Debra A., Morgan, Wayne J., Wright, Anne L., Lavi, Iris, Tarès, Lluïsa, Carsin, Anne-Elie, Dobaño, Carlota, Barreiro, Esther, Zock, Jan-Paul, Martínez-Moratalla, Jesús, Urrutia, Isabel, Sunyer, Jordi, Keidel, Dirk, Imboden, Medea, Probst-Hensch, Nicole, Hallberg, Jenny, Melén, Erik, Wickman, Magnus, Bousquet, Jean, Belgrave, Danielle C. M., Simpson, Angela, Custovic, Adnan, Antó, Josep M, Martinez, Fernando D
Format: Artigo
Langue:Inglês
Publié: 2015
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4640928/
https://ncbi.nlm.nih.gov/pubmed/26159408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S2213-2600(15)00196-4
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