Chronic mild stress and antidepressant treatment alter 5-HT1A receptor expression by modifying DNA methylation of a conserved Sp4 site

The serotonin 1A receptor (5-HT1A), a critical regulator of the brain serotonergic tone, is implicated in major depressive disorder (MDD) where it is often found to be dys-regulated. However, the extent to which stress and antidepressant treatment impact 5-HT1A expression in adults remains unclear....

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Veröffentlicht in:Neurobiol Dis
Hauptverfasser: Le François, Brice, Soo, Jeremy, Millar, Anne M., Daigle, Mireille, Le Guisquet, Anne-Marie, Leman, Samuel, Minier, Frédéric, Belzung, Catherine, Albert, Paul R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4640906/
https://ncbi.nlm.nih.gov/pubmed/26188176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2015.07.002
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