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VEGF-B-Neuropilin-1 signaling is spatiotemporally indispensable for vascular and neuronal development in zebrafish

Physiological functions of vascular endothelial growth factor (VEGF)-B remain an enigma, and deletion of the Vegfb gene in mice lacks an overt phenotype. Here we show that knockdown of Vegfba, but not Vegfbb, in zebrafish embryos by specific morpholinos produced a lethal phenotype owing to vascular...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Jensen, Lasse D., Nakamura, Masaki, Bräutigam, Lars, Li, Xuri, Liu, Yizhi, Samani, Nilesh J., Cao, Yihai
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4640767/
https://ncbi.nlm.nih.gov/pubmed/26483474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1510245112
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