Development of a diverse human T-cell repertoire despite stringent restriction of hematopoietic clonality in the thymus

The fate and numbers of hematopoietic stem cells (HSC) and their progeny that seed the thymus constitute a fundamental question with important clinical implications. HSC transplantation is often complicated by limited T-cell reconstitution, especially when HSC from umbilical cord blood are used. Att...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Brugman, Martijn H., Wiekmeijer, Anna-Sophia, van Eggermond, Marja, Wolvers-Tettero, Ingrid, Langerak, Anton W., de Haas, Edwin F. E., Bystrykh, Leonid V., van Rood, Jon J., de Haan, Gerald, Fibbe, Willem E., Staal, Frank J. T.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4640754/
https://ncbi.nlm.nih.gov/pubmed/26483497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1519118112
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