Erk signaling is indispensable for genomic stability and self-renewal of mouse embryonic stem cells

Inhibition of Mek/Erk signaling by pharmacological Mek inhibitors promotes self-renewal and pluripotency of mouse embryonic stem cells (ESCs). Intriguingly, Erk signaling is essential for human ESC self-renewal. Here we demonstrate that Erk signaling is critical for mouse ESC self-renewal and genomi...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Chen, Haixia, Guo, Renpeng, Zhang, Qian, Guo, Hongchao, Yang, Meng, Wu, Zhenfeng, Gao, Shan, Liu, Lin, Chen, Lingyi
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2015
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4640739/
https://ncbi.nlm.nih.gov/pubmed/26483458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1516319112
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