Identification and characterization of Runx2 phosphorylation sites involved in matrix metalloproteinase-13 promoter activation

Matrix metalloproteinase-13 (MMP-13) plays a critical role in parathyroid hormone (PTH)-induced bone resorption. PTH acts via protein kinase A (PKA) to phosphorylate and stimulate the transactivation of Runx2 for MMP-13 promoter activation. We show here that PTH stimulated Runx2 phosphorylation in r...

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Publicado en:FEBS Lett
Autores principales: Selvamurugan, Nagarajan, Shimizu, Emi, Lee, Minnkyong, Liu, Tong, Li, Hong, Partridge, Nicola C.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2009
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4640702/
https://ncbi.nlm.nih.gov/pubmed/19264160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2009.02.040
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