Selective astrocytic endothelin-1 overexpression contributes to dementia associated with ischemic stroke by exaggerating astrocyte-derived amyloid secretion

Endothelin-1 (ET-1) is synthesized by endothelial cells and astrocytes in stroke and in brains of Alzheimer's disease patients. Our transgenic mice with ET-1 overexpression in the endothelial cells (TET-1) showed more severe blood–brain barrier (BBB) breakdown, neuronal apoptosis, and glial rea...

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Detalhes bibliográficos
Publicado no:J Cereb Blood Flow Metab
Main Authors: Hung, Victor K L, Yeung, Patrick K K, Lai, Angela K W, Ho, Maggie C Y, Lo, Amy C Y, Chan, Kevin C, Wu, Ed X K, Chung, Stephen S M, Cheung, Chi W, Chung, Sookja K
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4640314/
https://ncbi.nlm.nih.gov/pubmed/26104290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2015.109
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