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Human caspase-4 and caspase-5 regulate the one-step non-canonical inflammasome activation in monocytes
Monocytes promote the early host response to infection releasing key pro-inflammatory cytokines, such as IL-1β. The biologically inactive IL-1β precursor is processed to active form by inflammasomes, multi-protein complexes activating caspase-1. Human monocytes exhibit an unconventional one-step pat...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Pub. Group
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4640152/ https://ncbi.nlm.nih.gov/pubmed/26508369 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9761 |
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