Endosomal sorting of Notch receptors through COMMD9-dependent pathways modulates Notch signaling

Notch family members are transmembrane receptors that mediate essential developmental programs. Upon ligand binding, a proteolytic event releases the intracellular domain of Notch, which translocates to the nucleus to regulate gene transcription. In addition, Notch trafficking across the endolysosom...

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Dettagli Bibliografici
Pubblicato in:J Cell Biol
Autori principali: Li, Haiying, Koo, Yeon, Mao, Xicheng, Sifuentes-Dominguez, Luis, Morris, Lindsey L., Jia, Da, Miyata, Naoteru, Faulkner, Rebecca A., van Deursen, Jan M., Vooijs, Marc, Billadeau, Daniel D., van de Sluis, Bart, Cleaver, Ondine, Burstein, Ezra
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2015
Soggetti:
Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4639872/
https://ncbi.nlm.nih.gov/pubmed/26553930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201505108
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