COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A

COMMD1 deficiency results in defective copper homeostasis, but the mechanism for this has remained elusive. Here we report that COMMD1 is directly linked to early endosomes through its interaction with a protein complex containing CCDC22, CCDC93, and C16orf62. This COMMD/CCDC22/CCDC93 (CCC) complex...

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Publicado no:Mol Biol Cell
Main Authors: Phillips-Krawczak, Christine A., Singla, Amika, Starokadomskyy, Petro, Deng, Zhihui, Osborne, Douglas G., Li, Haiying, Dick, Christopher J., Gomez, Timothy S., Koenecke, Megan, Zhang, Jin-San, Dai, Haiming, Sifuentes-Dominguez, Luis F., Geng, Linda N., Kaufmann, Scott H., Hein, Marco Y., Wallis, Mathew, McGaughran, Julie, Gecz, Jozef, van de Sluis, Bart, Billadeau, Daniel D., Burstein, Ezra
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2015
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4279232/
https://ncbi.nlm.nih.gov/pubmed/25355947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E14-06-1073
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