Anti-emetic drug maropitant induces intestinal motility disorder but not anti-inflammatory action in mice

Maropitant is a neurokinin 1 receptor (NK1R) antagonist that is clinically used as a new anti-emetic drug for dogs. Substance P (SP) and its receptor NK1R are considered to modulate gastrointestinal peristalsis. In addition, SP works as an inflammatory mediator in gastrointestinal diseases. Aim of t...

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Опубликовано в: :J Vet Med Sci
Главные авторы: MIKAWA, Shoma, YAMAMOTO, Shohei, ISLAM, Md Shafiqul, KAJI, Noriyuki, MURATA, Takahisa, MIZUNO, Risuke, OZAKI, Hiroshi, HORI, Masatoshi
Формат: Artigo
Язык:Inglês
Опубликовано: The Japanese Society of Veterinary Science 2015
Предметы:
Pharmacology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4638283/
https://ncbi.nlm.nih.gov/pubmed/25947563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1292/jvms.15-0182
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