Proteomic and Biochemical Studies of Lysine Malonylation Suggest Its Malonic Aciduria-associated Regulatory Role in Mitochondrial Function and Fatty Acid Oxidation

The protein substrates of sirtuin 5-regulated lysine malonylation (Kmal) remain unknown, hindering its functional analysis. In this study, we carried out proteomic screening, which identified 4042 Kmal sites on 1426 proteins in mouse liver and 4943 Kmal sites on 1822 proteins in human fibroblasts. I...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Mol Cell Proteomics
Main Authors: Colak, Gozde, Pougovkina, Olga, Dai, Lunzhi, Tan, Minjia, te Brinke, Heleen, Huang, He, Cheng, Zhongyi, Park, Jeongsoon, Wan, Xuelian, Liu, Xiaojing, Yue, Wyatt W., Wanders, Ronald J. A., Locasale, Jason W., Lombard, David B., de Boer, Vincent C. J., Zhao, Yingming
פורמט: Artigo
שפה:Inglês
יצא לאור: The American Society for Biochemistry and Molecular Biology 2015
נושאים:
Research
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4638046/
https://ncbi.nlm.nih.gov/pubmed/26320211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M115.048850
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