Proteomic and Biochemical Studies of Lysine Malonylation Suggest Its Malonic Aciduria-associated Regulatory Role in Mitochondrial Function and Fatty Acid Oxidation

The protein substrates of sirtuin 5-regulated lysine malonylation (Kmal) remain unknown, hindering its functional analysis. In this study, we carried out proteomic screening, which identified 4042 Kmal sites on 1426 proteins in mouse liver and 4943 Kmal sites on 1822 proteins in human fibroblasts. I...

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Veröffentlicht in:Mol Cell Proteomics
Hauptverfasser: Colak, Gozde, Pougovkina, Olga, Dai, Lunzhi, Tan, Minjia, te Brinke, Heleen, Huang, He, Cheng, Zhongyi, Park, Jeongsoon, Wan, Xuelian, Liu, Xiaojing, Yue, Wyatt W., Wanders, Ronald J. A., Locasale, Jason W., Lombard, David B., de Boer, Vincent C. J., Zhao, Yingming
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Biochemistry and Molecular Biology 2015
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Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4638046/
https://ncbi.nlm.nih.gov/pubmed/26320211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M115.048850
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