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DNA promoter hypermethylation contributes to down-regulation of galactocerebrosidase gene in lung and head and neck cancers
Galactocerebrosidase (GALC) is a lysosomal enzyme responsible for glycosphingolipids degradation byproducts of which are important for synthesis of apoptosis mediator ceramide. Reduced expression of GALC has been identified in human malignancies; however, molecular mechanisms underlying down-regulat...
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| Publié dans: | Int J Clin Exp Pathol |
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| Auteurs principaux: | , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
e-Century Publishing Corporation
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4637637/ https://ncbi.nlm.nih.gov/pubmed/26617822 |
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