Activation of unfolded protein response protects osteosarcoma cells from cisplatin-induced apoptosis through NF-κB pathway

The aim of this study was to uncover that unfolded protein response (UPR) contributed to the development of cisplatin resistance in osteosarcoma. MG-63 cells and SaOS-2 cells were exposed to cisplatin at presence or absence of 4-phenylbutyrayte (4-pba) and then analyzed by MTT assay and flow cytomet...

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Veröffentlicht in:Int J Clin Exp Pathol
Hauptverfasser: Yan, Mingming, Ni, Jiangdong, Song, Deye, Ding, Muliang, Huang, Jun
Format: Artigo
Sprache:Inglês
Veröffentlicht: e-Century Publishing Corporation 2015
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4637544/
https://ncbi.nlm.nih.gov/pubmed/26617729
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