Dectin-1 Activation by a Natural Product β-Glucan Converts Immunosuppressive Macrophages into an M1-like Phenotype

Tumor-associated macrophages (TAM) with an M2-like phenotype have been linked to tumor-elicited inflammation, immunosuppression, and resistance to chemotherapies in cancer, thus representing an attractive target for an effective cancer immunotherapy. Here, we demonstrate that particulate yeast-deriv...

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Bibliografiske detaljer
Udgivet i:J Immunol
Main Authors: Liu, Min, Luo, Fengling, Ding, Chuanlin, Albeituni, Sabrin, Hu, Xiaoling, Ma, Yunfeng, Cai, Yihua, McNally, Lacey, Sanders, Mary Ann, Jain, Dharamvir, Kloecker, Goetz, Bousamra, Michael, Zhang, Huang-ge, Higashi, Richard M., Lane, Andrew N., Fan, Teresa W-M., Yan, Jun
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4637216/
https://ncbi.nlm.nih.gov/pubmed/26453753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1501158
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