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Prevention of Abdominal Aortic Aneurysm Progression by Targeted Inhibition of Matrix Metalloproteinase Activity with Batimastat-Loaded Nanoparticles

RATIONALE: Matrix metalloproteinases (MMPs)-mediated extracellular matrix destruction is the major cause of development and progression of abdominal aortic aneurysms (AAA). Systemic treatments of MMP inhibitors have shown effectiveness in animal models but it did not translate to clinical success ei...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Circ Res
Hauptverfasser: Nosoudi, Nasim, Nahar-Gohad, Pranjal, Sinha, Aditi, Chowdhury, Aniqa, Gerard, Patrick, Carsten, Christopher G., Gray, Bruce H., Vyavahare, Naren R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4636940/
https://ncbi.nlm.nih.gov/pubmed/26443597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.115.307207
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