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A Peptide Uncoupling BDNF Receptor TrkB from Phospholipase Cγ1 Prevents Epilepsy Induced by Status Epilepticus

The BDNF receptor tyrosine kinase, TrkB, underlies nervous system function in both health and disease. Excessive activation of TrkB caused by status epilepticus promotes development of temporal lobe epilepsy (TLE), revealing TrkB as a therapeutic target for prevention of TLE. To circumvent undesirab...

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Publicado en:Neuron
Main Authors: Gu, Bin, Huang, Yang Zhong, He, Xiao-Ping, Joshi, Rasesh B., Jang, Wonjo, McNamara, James O.
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4636438/
https://ncbi.nlm.nih.gov/pubmed/26481038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2015.09.032
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