Excess TGF-β mediates muscle weakness associated with bone metastases in mice

Cancer-associated muscle weakness is poorly understood and there is no effective treatment. Here, we find that seven different mouse models of human osteolytic bone metastases, representing breast, lung and prostate cancers, as well as multiple myeloma exhibited impaired muscle function, implicating...

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Detalhes bibliográficos
Publicado no:Nat Med
Main Authors: Waning, David L., Mohammad, Khalid S., Reiken, Steven, Xie, Wenjun, Andersson, Daniel C., John, Sutha, Chiechi, Antonella, Wright, Laura E., Umanskaya, Alisa, Niewolna, Maria, Trivedi, Trupti, Charkhzarrin, Sahba, Khatiwada, Pooja, Wronska, Anetta, Haynes, Ashley, Benassi, Maria Serena, Witzmann, Frank A., Zhen, Gehua, Wang, Xiao, Cao, Xu, Roodman, G. David, Marks, Andrew R., Guise, Theresa A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4636436/
https://ncbi.nlm.nih.gov/pubmed/26457758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3961
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