Excess TGF-β mediates muscle weakness associated with bone metastases in mice

Cancer-associated muscle weakness is poorly understood and there is no effective treatment. Here, we find that seven different mouse models of human osteolytic bone metastases, representing breast, lung and prostate cancers, as well as multiple myeloma exhibited impaired muscle function, implicating...

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Опубликовано в: :Nat Med
Главные авторы: Waning, David L., Mohammad, Khalid S., Reiken, Steven, Xie, Wenjun, Andersson, Daniel C., John, Sutha, Chiechi, Antonella, Wright, Laura E., Umanskaya, Alisa, Niewolna, Maria, Trivedi, Trupti, Charkhzarrin, Sahba, Khatiwada, Pooja, Wronska, Anetta, Haynes, Ashley, Benassi, Maria Serena, Witzmann, Frank A., Zhen, Gehua, Wang, Xiao, Cao, Xu, Roodman, G. David, Marks, Andrew R., Guise, Theresa A.
Формат: Artigo
Язык:Inglês
Опубликовано: 2015
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4636436/
https://ncbi.nlm.nih.gov/pubmed/26457758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3961
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