Increased frequency of ICOS(+) CD4 T-cells as a pharmacodynamic biomarker for anti-CTLA-4 therapy

Pharmacodynamic biomarkers can play an important role in understanding whether a therapeutic agent has “hit its target” to impact biologic function. A pharmacodynamic biomarker for anti-CTLA-4 therapy remains to be elucidated. We previously reported that anti-CTLA-4 therapy increases the frequency o...

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Gepubliceerd in:Cancer Immunol Res
Hoofdauteurs: Tang, Derek Ng, Shen, Yu, Sun, Jingjing, Wen, Sijin, Wolchok, Jedd D., Yuan, Jianda, Allison, James P., Sharma, Padmanee
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2013
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4636341/
https://ncbi.nlm.nih.gov/pubmed/24777852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-13-0020
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