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Synergistic Effect and Molecular Mechanism of Homoharringtonine and Bortezomib on SKM-1 Cell Apoptosis

BACKGROUND: Myelodysplastic syndromes (MDS) are clonal marrow stem-cell disorders with a high risk of progression to acute myeloid leukemia (AML). Treatment options are limited and targeted therapies are not available for MDS. In the present study, we investigated the cytotoxicity and the molecular...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Zhang, Jing, Chen, Bobin, Wu, Ting, Wang, Qian, Zhuang, Lin, Zhu, Chen, Fan, Ni, Qing, Wenjiao, Ma, Yan, Xu, Xiaoping
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4636319/
https://ncbi.nlm.nih.gov/pubmed/26544558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0142422
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