Homoharringtonine combined with aclarubicin and cytarabine synergistically induces apoptosis in t(8;21) leukemia cells and triggers caspase‐3‐mediated cleavage of the AML1‐ETO oncoprotein

Homoharringtonine combined with aclarubicin and cytarabine (HAA) is a highly effective treatment for acute myeloid leukemia (AML), especially for t(8;21) AML. However, the underlying mechanisms by which HAA kills t(8;21) AML cells remain unclear. In this study, SKNO‐1 and Kasumi‐1 cells with t(8;21)...

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Vydáno v:Cancer Med
Hlavní autoři: Cao, Jiang, Feng, Hao, Ding, Ning‐Ning, Wu, Qing‐yun, Chen, Chong, Niu, Ming‐Shan, Chen, Wei, Qiu, Ting‐Ting, Zhu, Hong‐Hu, Xu, Kai‐Lin
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2016
Témata:
Cancer Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5119976/
https://ncbi.nlm.nih.gov/pubmed/27709797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cam4.913
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