Structural basis for receptor subtype-specific regulation revealed by a chimeric beta 3/beta 2-adrenergic receptor.

The physiological significance of multiple G-protein-coupled receptor subtypes, such as the beta-adrenergic receptors (beta ARs), remains obscure, since in many cases several subtypes activate the same effector and utilize the same physiological agonists. We inspected the deduced amino acid sequence...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Liggett, S B, Freedman, N J, Schwinn, D A, Lefkowitz, R J
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1993
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC46362/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8386380/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.8.3665
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