Lysine Methylation of the Valosin-Containing Protein (VCP) Is Dispensable for Development and Survival of Mice

Valosin-containing protein (VCP) is a homohexameric ATPase involved in a multitude cellular processes and it was recently shown that VCP is trimethylated at lysine 315 by the VCP lysine methyltransferase (VCPKMT). Here, we generated and validated a constitutive knockout mouse by targeting exon 1–4 o...

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Detalles Bibliográficos
Publicado en:PLoS One
Main Authors: Fusser, Markus, Kernstock, Stefan, Aileni, Vinay Kumar, Egge-Jacobsen, Wolfgang, Falnes, Pål Ø., Klungland, Arne
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2015
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4636187/
https://ncbi.nlm.nih.gov/pubmed/26544960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0141472
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