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Obesity promotes colonic stem cell expansion during cancer initiation

There is an urgent need to elucidate the mechanistic links between obesity and colon cancer. Convincing evidence for the role of Lgr5(+)stem cells in colon tumorigenesis has been established, however, the influence of obesity on stem cell maintenance is unknown. We assessed the effects of high fat (...

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Bibliografiske detaljer
Udgivet i:Cancer Lett
Main Authors: DeClercq, McMurray, DN, Chapkin, RS
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4636003/
https://ncbi.nlm.nih.gov/pubmed/26455770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2015.10.001
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