p38 MAPK mediates glial P2X7R-neuronal P2Y1R inhibitory control of P2X3R expression in dorsal root ganglion neurons

BACKGROUND: We have previously shown that endogenously active purinergic P2X7 receptors (P2X7Rs) in satellite glial cells of dorsal root ganglia (DRGs) stimulate ATP release. The ATP activates P2Y1Rs located in the enwrapped neuronal somata, resulting in down-regulation of P2X3Rs. This P2X7R-P2Y1-P2...

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Enregistré dans:
Détails bibliographiques
Publié dans:Mol Pain
Auteurs principaux: Chen, Yong, Li, Guangwen, Huang, Li-Yen Mae
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2015
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4635984/
https://ncbi.nlm.nih.gov/pubmed/26542462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12990-015-0073-7
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