p38 MAPK mediates glial P2X7R-neuronal P2Y1R inhibitory control of P2X3R expression in dorsal root ganglion neurons

BACKGROUND: We have previously shown that endogenously active purinergic P2X7 receptors (P2X7Rs) in satellite glial cells of dorsal root ganglia (DRGs) stimulate ATP release. The ATP activates P2Y1Rs located in the enwrapped neuronal somata, resulting in down-regulation of P2X3Rs. This P2X7R-P2Y1-P2...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Mol Pain
Egile Nagusiak: Chen, Yong, Li, Guangwen, Huang, Li-Yen Mae
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: BioMed Central 2015
Gaiak:
Research
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4635984/
https://ncbi.nlm.nih.gov/pubmed/26542462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12990-015-0073-7
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