Engineered biosynthesis of enduracidin lipoglycopeptide antibiotics using the ramoplanin mannosyltransferase Ram29

The lipopeptides ramoplanin from Actinoplanes sp. ATCC 33076 and enduracidin produced by Streptomyces fungicidicus are effective antibiotics against a number of drug-resistant Gram-positive pathogens. While these two antibiotics share a similar cyclic peptide structure, comprising 17 amino acids wit...

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Publicado en:Microbiology (Reading)
Autores principales: Wu, Ming-Cheng, Styles, Matthew Q., Law, Brian J. C., Struck, Anna-Winona, Nunns, Laura, Micklefield, Jason
Formato: Artigo
Lenguaje:Inglês
Publicado: Society for General Microbiology 2015
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4635501/
https://ncbi.nlm.nih.gov/pubmed/25878261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1099/mic.0.000095
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