Permissivity of primary hepatocytes and hepatoma cell lines to support hepatitis C virus infection

The major cell type supporting hepatitis C virus (HCV) infection is the hepatocyte; however, most reports studying viral entry and replication utilize transformed hepatoma cell lines. We demonstrate that HCV pseudoparticles (HCVpp) infect primary hepatocytes with comparable rates to hepatoma cells,...

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Bibliographic Details
Published in:J Gen Virol
Main Authors: Wilson, Garrick K., Farquhar, Michelle J., Meredith, Luke, Dhawan, Anil, Mitry, Ragai, Balfe, Peter, McKeating, Jane A.
Format: Artigo
Language:Inglês
Published: Society for General Microbiology 2015
Subjects:
Animal
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4635487/
https://ncbi.nlm.nih.gov/pubmed/25667327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1099/vir.0.000085
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