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Polarization Restricts Hepatitis C Virus Entry into HepG2 Hepatoma Cells

The primary reservoir for hepatitis C virus (HCV) replication is believed to be hepatocytes, which are highly polarized with tight junctions (TJ) separating their basolateral and apical domains. HepG2 cells develop polarity over time, resulting in the formation and remodeling of bile canalicular (BC...

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Autores principales: Mee, Christopher J., Harris, Helen J., Farquhar, Michelle J., Wilson, Garrick, Reynolds, Gary, Davis, Christopher, van IJzendoorn, Sven C. D., Balfe, Peter, McKeating, Jane A.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology (ASM) 2009
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2687400/
https://ncbi.nlm.nih.gov/pubmed/19357163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00246-09
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