Cathepsin L acutely alters microvessel integrity within the neurovascular unit during focal cerebral ischemia

During focal cerebral ischemia, the degradation of microvessel basal lamina matrix occurs acutely and is associated with edema formation and microhemorrhage. These events have been attributed to matrix metalloproteinases (MMPs). However, both known protease generation and ligand specificities sugges...

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Publicat a:J Cereb Blood Flow Metab
Autors principals: Gu, Yu-Huan, Kanazawa, Masato, Hung, Stephanie Y, Wang, Xiaoyun, Fukuda, Shunichi, Koziol, James A, del Zoppo, Gregory J
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2015
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4635247/
https://ncbi.nlm.nih.gov/pubmed/26198177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2015.170
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