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Cathepsin L acutely alters microvessel integrity within the neurovascular unit during focal cerebral ischemia

During focal cerebral ischemia, the degradation of microvessel basal lamina matrix occurs acutely and is associated with edema formation and microhemorrhage. These events have been attributed to matrix metalloproteinases (MMPs). However, both known protease generation and ligand specificities sugges...

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Detalhes bibliográficos
Publicado no:J Cereb Blood Flow Metab
Main Authors: Gu, Yu-Huan, Kanazawa, Masato, Hung, Stephanie Y, Wang, Xiaoyun, Fukuda, Shunichi, Koziol, James A, del Zoppo, Gregory J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4635247/
https://ncbi.nlm.nih.gov/pubmed/26198177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2015.170
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