20-Hydroxyeicosatetraenoic Acid Inhibition by HET0016 Offers Neuroprotection, Decreases Edema, and Increases Cortical Cerebral Blood Flow in a Pediatric Asphyxial Cardiac Arrest Model in Rats

Vasoconstrictive and vasodilatory eicosanoids generated after cardiac arrest (CA) may contribute to cerebral vasomotor disturbances and neurodegeneration. We evaluated the balance of vasodilator/vasoconstrictor eicosanoids produced by cytochrome P450 (CYP) metabolism, and determined their role on co...

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Vydáno v:J Cereb Blood Flow Metab
Hlavní autoři: Shaik, Jafar Sadik B, Poloyac, Samuel M, Kochanek, Patrick M, Alexander, Henry, Tudorascu, Dana L, Clark, Robert SB, Manole, Mioara D
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2015
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4635230/
https://ncbi.nlm.nih.gov/pubmed/26058691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2015.117
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