Quantification of sphingosine 1-phosphate by validated LC-MS/MS method revealing strong correlation with apolipoprotein M in plasma but not in serum due to platelet activation during blood coagulation

Sphingosine 1-phosphate (S1P) is a signalling sphingolipid affecting multiple cellular functions of vascular and immune systems. It circulates at submicromolar levels bound to HDL-associated apolipoprotein M (apoM) or to albumin. S1P in blood is mainly produced by platelets and erythrocytes, making...

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Опубликовано в: :Anal Bioanal Chem
Главные авторы: Frej, Cecilia, Andersson, Anders, Larsson, Benny, Guo, Li Jun, Norström, Eva, Happonen, Kaisa E., Dahlbäck, Björn
Формат: Artigo
Язык:Inglês
Опубликовано: Springer Berlin Heidelberg 2015
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Research Paper
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4635185/
https://ncbi.nlm.nih.gov/pubmed/26377937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00216-015-9008-4
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