Partial reconstitution of humoral immunity and fewer infections in patients with chronic lymphocytic leukemia treated with ibrutinib

Chronic lymphocytic leukemia (CLL) is characterized by immune dysregulation, often including hypogammaglobulinemia, which contributes to a high rate of infections and morbidity. Ibrutinib, a covalent inhibitor of Bruton tyrosine kinase (BTK), inhibits B-cell receptor signaling and is an effective, U...

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Bibliographische Detailangaben
Veröffentlicht in:Blood
Hauptverfasser: Sun, Clare, Tian, Xin, Lee, Yuh Shan, Gunti, Sreenivasulu, Lipsky, Andrew, Herman, Sarah E. M., Salem, Dalia, Stetler-Stevenson, Maryalice, Yuan, Constance, Kardava, Lela, Moir, Susan, Maric, Irina, Valdez, Janet, Soto, Susan, Marti, Gerald E., Farooqui, Mohammed Z., Notkins, Abner L., Wiestner, Adrian, Aue, Georg
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2015
Schlagworte:
Lymphoid Neoplasia
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4635117/
https://ncbi.nlm.nih.gov/pubmed/26337493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-04-639203
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