Partial reconstitution of humoral immunity and fewer infections in patients with chronic lymphocytic leukemia treated with ibrutinib

Chronic lymphocytic leukemia (CLL) is characterized by immune dysregulation, often including hypogammaglobulinemia, which contributes to a high rate of infections and morbidity. Ibrutinib, a covalent inhibitor of Bruton tyrosine kinase (BTK), inhibits B-cell receptor signaling and is an effective, U...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Sun, Clare, Tian, Xin, Lee, Yuh Shan, Gunti, Sreenivasulu, Lipsky, Andrew, Herman, Sarah E. M., Salem, Dalia, Stetler-Stevenson, Maryalice, Yuan, Constance, Kardava, Lela, Moir, Susan, Maric, Irina, Valdez, Janet, Soto, Susan, Marti, Gerald E., Farooqui, Mohammed Z., Notkins, Abner L., Wiestner, Adrian, Aue, Georg
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2015
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4635117/
https://ncbi.nlm.nih.gov/pubmed/26337493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-04-639203
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